Potential CBD Side Effects & Safety

The overall safety profile of any given compound, as well as its potential risk of adverse side-effects, is paramount to a consumer’s well-being. As is the case for every symptom-relieving substance, CBD has been reported to potentially cause specific side effects, though these have proven to be both mild and easily manageable. In this article, let’s take a closer look at the potential side-effects of CBD and its overall safety profile.


Cannabidiol, known more commonly as CBD, is a plant-based chemical compound unique to the cannabis sativa L genus. Secreted by both cannabis (marijuana) and hemp plants, CBD has been scientifically accredited with a host of therapeutic benefits and potential health applications. Consumers on a global scale utilize this organic, all-natural compound to help manage symptoms associated with a host of conditions and disorders, including (but not limited to):

  • Anxiety
  • Depression
  • Gastrointestinal (GI) issues
  • Neurodegenerative diseases
  • Pain management
  • Sleep disorders

CBD sourced from industrial hemp is completely legal in all 50 states and in many countries around the world. It can easily be acquired in a variety of outlets, though CBD-infused products are most commonly purchased through an online vendor.

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Cannabinoids such as CBD have a profound interaction with our internal endocannabinoid system (ECS), which is an extremely complex endogenous network of endocannabinoids, their metabolic enzymes, and highly specialized receptors. Responsible for establishing and maintaining overall health and wellness by promoting a state of homeostasis within the body, the ECS regulates crucial bodily functions such as mood, sleep, appetite, pain, and immune system health.


While there have been a few reported possible adverse side-effects associated with CBD consumption, these have proven to be mild and easily manageable. For instance, “dry mouth1 is a characteristic commonly correlated with CBD that can easily be remedied by drinking water before and after dose administration.

While CBD typically has a stimulating effect in small to moderate doses, some consumers report symptoms of low-energy and general tiredness.2 This effect has prompted many CBD-focused sleep studies with incredibly promising results. Consuming CBD before bed as a sleep aid is an excellent way to manage this potential side-effect and could, in turn, promote quality sleep and help restore balance to your sleep/wake cycle.

Perhaps more severe but still no cause for alarm, a direct link has been established between CBD and a slight initial drop in blood pressure (BP).3 While this potential side-effect could be desirable for some (especially those diagnosed with hypertension and/or other cardiovascular problems), blood pressure quickly re-stabilizes after this initial drop.

The final commonly reported CBD side-effect most likely stems from the aforementioned initial drop in blood pressure. Some consumers experience a brief period of dizziness or “lightheadedness” shortly after consumption.4 However, once blood pressure begins to re-stabilize, the spell quickly passes. To combat this potential bothersome effect, be sure to administer CBD while in the seated position until the dizzy period elapses.


Through rigorous testing and in-depth research, CBD has proven time and time again to be incredibly well-tolerated with minimal risk of adverse side-effects. In support of this claim, the World Health Organization (WHO) released an international disclosure in 2017, in which it was reported that “CBD is generally well tolerated with a good safety profile.” The report further elaborates on potential unintended side-effects by stating: “Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications.”


Virtually every chemical compound has the potential to interact with other substances in a way that creates adverse or otherwise unpleasant effects. For instance, CBD has demonstrated unintended side-effects when consumed simultaneously with certain prescription medications such as anti-depressants, blood thinners, antipsychotics, and certain pain-management drugs.

To ensure safe practices, especially for those under the daily influence of certain prescribed pharmaceutical medications, it is essential to first consult with a healthcare professional before beginning a CBD regimen.


Despite being a generally very well-tolerated compound that is not directly associated with any significant adverse public health effects, CBD affects everyone differently due to differences in body weight, symptom severity, and chemical makeup. Therefore, it would be good practice for beginners to start with small doses as an attempt to gauge potential unanticipated effects. Once you understand how a daily CBD regimen affects you personally, gradually increase dose strength until optimum therapeutic results are achieved.


Here at Hempindica, we are proud to offer a wide selection of products infused with only the highest quality hemp-derived CBD attainable. We proudly ship to all 50 states and offer free priority shipping on all orders! Browse our site by category and be sure not to miss out on our featured product offerings!

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